|
T22714 |
Decynium 22
|
|
Others
|
|
Decynium 22 is a plasma membrane monoamine transporter (PMAT) inhibitor |
|
T39429 |
AHN 1-055 hydrochloride
|
3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride |
Dopamine Receptor
|
|
AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM). |
|
T1993 |
J-147
|
J147 |
Epigenetic Reader Domain
,
Dopamine Receptor
,
Monoamine Oxidase
|
|
J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate... |
|
T0322 |
Fipexide
|
|
Dopamine Receptor
,
AChR
|
|
Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is... |
|
T7341 |
Diclofensine
|
Ro 8-4650 |
Dopamine Receptor
,
Monoamine Transporter
|
|
Diclofensine (Ro 8-4650) inhibits the uptake of serotonin, noradrenaline and dopamine. |
|
T11087 |
DOV-216,303 Free Base
|
DOV-216303 |
Dopamine Receptor
,
Serotonin Transporter
,
Norepinephrine
|
|
|
|
T6414 |
Bisacodyl
|
Fenilaxan,Dulcolax,Brocalax |
Others
|
|
Bisacodyl (Fenilaxan) is a diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation. |
|
T10758L |
Centanafadine hydrochloride
|
EB-1020 hydrochloride |
Dopamine Receptor
,
Serotonin Transporter
,
Adrenergic Receptor
,
Norepinephrine
|
|
Centanafadine hydrochloride (EB-1020 hydrochloride) is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin... |
|
T3526 |
Dasotraline hydrochloride
|
SEP-225289 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
|
|
Dasotraline hydrochloride (SEP-225289 hydrochloride) (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respe... |
|
T1871 |
GBR 12935 dihydrochloride
|
GBR12935,GBR-12935,GBR 12935 |
Dopamine Receptor
|
|
GBR 12935 dihydrochloride (GBR 12935) can induce the increase of the extracellular levels of dopamine to basal levels. |
|
T0766 |
Promazine hydrochloride
|
Romtiazin hydrochloride,Sinophenin hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
|
|
Promazine hydrochloride (Romtiazin hydrochloride) is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as ... |
|
T1336 |
Benztropine mesylate
|
Benzotropine mesylate,Benzatropine mesylate,Benztropine methanesulfonate |
Dopamine Receptor
,
AChR
,
Histamine Receptor
|
|
Benztropine mesylate (Benztropine methanesulfonate) is a centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine. |
|
T2092 |
Amitifadine hydrochloride
|
DOV-21947 hydrochloride,EB-1010 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
|
|
Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). |
|
T0991 |
Desipramine hydrochloride
|
NSC-114901,Desmethylimipramine,JB-8181,EX-4355,Norimipramine,G-35020 |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Adrenergic Receptor
|
|
Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-upt... |
|
T7745 |
Diclofensine hydrochloride
|
Ro 8-4650 hydrochloride |
Others
,
Dopamine Receptor
|
|
Diclofensine hydrochloride (Ro 8-4650 hydrochloride) is a Novel Antidepressant, on Peripheral Adrenergic Function |
|
T7153 |
Vanoxerine dihydrochloride
|
GBR-12909 dihydrochloride,I893 dihydrochloride |
Dopamine Receptor
|
|
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a potent inhibitor that blocks dopamine uptake (IC50 : 1-51 nM) |
|
T23234 |
Rimcazole dihydrochloride
|
|
Others
|
|
Rimcazole dihydrochloride is the hydrochloride salt of Rimcazole, a σ receptor antagonist. Rimcazole dihydrochloride also binds to dopamine transporter proteins and inhibits dopamine uptake. |
|
T7734 |
BETA-CFT sulfate
|
|
Others
|
|
BETA-CFT sulfate is a derivative of BETA-CFT, an antagonist of dopamine transporter proteins (DATs). |
|
T0948 |
Adrenalone hydrochloride
|
Adrenalone HCl |
Adrenergic Receptor
|
|
Adrenalone hydrochloride (Adrenalone HCl) is a dopamine β-oxidase inhibitor with a similar structure to the norepinephrine transporter (NET) ligand, with an IC50 of 36.9 μM. It is an adrenergic agonist that acts as a loc... |
|
T41194 |
FFN 102 mesylate
|
|
Others
|
|
FFN 102 mesylate is a pH responsive fluorescent false neurotransmitter (FFN), a selective dopamine transporter (DAT) and VMAT2 substrate. Exhibits no significant binding to a panel of 38 CNS receptors, including dopamine... |
|
T9169 |
MPP+ iodide
|
|
Mitochondrial Metabolism
,
Autophagy
|
|
MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) ex... |
|
T22959 |
M-Chlorophenylbiguanide hydrochloride
|
1-(3-Chlorophenyl)biguanidehydrochloride |
5-HT Receptor
|
|
5-HT3 receptor agonist |
|
T0255 |
Clomipramine hydrochloride
|
Clomipramine HCl,Anafranil |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
,
GST
|
|
Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demeth... |
|
T0869 |
Atomoxetine hydrochloride
|
Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,LY 139603,Atomoxetine HCl,LY 139603 HCl |
Dopamine Receptor
,
5-HT Receptor
,
Norepinephrine
|
|
Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Althou... |
|
T24712 |
Rimcazole
|
|
|
|
Rimcazole is a sigma receptor antagonist. It also binds to the dopamine transporter and inhibiting dopamine uptake. |
|
T29920 |
Altropane
|
|
|
|
Altropane is a SPECT imaging agent used for viewing dopamine transporter sites. |
|
T23501 |
Vanoxerine
|
|
Others
|
|
Vanoxerine is an antagonist of dopamine transporter (Ki: 16.9nM). |
|
T26145 |
RTI 336
|
RTI336,RTI-336 |
|
|
RTI 336 is used as a chronic brain dopamine transporter (DAT) inhibitor. |
|
T10758 |
Centanafadine
|
EB-1020 |
Others
|
|
Centanafadine is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter). |
|
T27036 |
CL-216303 HCl
|
DOV-216303,DOV216303,CL 216303,CL-216303,DOV 216303,CL216303 |
|
|
CL-216303 HCl, a dopamine transporter inhibitor and a 5-HT inhibitor, is used potentially for the treatment of depression. |
|
T36949 |
Niaprazine
|
|
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research[1][2].
Niaprazine exhibits a low aff... |
|
T10842 |
Clomipramine D3
|
|
Others
|
|
Clomipramine D3 is the deuterium-labeled Clomipramine. Clomipramine is a serotonin transporter, norepinephrine transporter dopamine transporter blocker (Ki: 0.14, 54 and 3 nM). |
|
T10842L |
Clomipramine D3 hydrochloride
|
|
Others
|
|
Clomipramine D3 hydrochloride is the deuterium-labeled Clomipramine. Clomipramine is a serotonin transporter, norepinephrine transporter dopamine transporter blocker (Ki: 0.14, 54 and 3 nM). |
|
T27689 |
JNJ-7925476 HCl
|
JNJ-7925476,JNJ7925476,JNJ 7925476 |
|
|
JNJ-7925476 HCl is a triple monoamine uptake inhibitor. JNJ-7925476 Salt blocks the dopamine transporter (DAT), norepinephrine transporter (NET) and serotonin transporter (SERT) in the central nervous system. The ED(50) ... |
|
T24956 |
(18F)LBT 999
|
(18F)LBT999,LBT999 18F,LBT 999 18F,LBT-999 18F,(18F)LBT-999 |
|
|
(18F)LBT 999 is a positron emission tomography (PET) tracer, used for the quantification of the dopamine transporter (DAT) in the healthy rat brain. |
|
T37699 |
Org 24598
|
|
|
|
Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transport... |
|
T31758 |
Fecnt F-18
|
J2.661.350G,18F-Fecnt,(18F)-Fecnt |
|
|
[F-18] FECNT has been widely used to calculate dopamine transporter (DAT) occupancy rates in the brains of non-human primates and can distinguish DAT density differences between Parkinson's disease and healthy human cont... |
|
T70615 |
TAS-303
|
|
|
|
TAS-303 is a selective norepinephrine reuptake inhibitor which displays significant norepinephrine transporter (NET) inhibitory activity toward serotonin or dopamine transporters. Radioligand-binding studies showed that ... |
|
T79264 |
Z1078601926
|
|
|
|
Z1078601926 is an allosteric inhibitor of the human dopamine transporter (hDAT) and exhibits a synergistic effect when combined with Nomifensine [1]. |
|
T71772 |
Bicifadine free base
|
|
|
|
Bicifadine, also known as DOV-220075, CL 220,075, is a SNDR inhibitor potentially for the treatment of lower back pain. Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less ... |
|
T70914 |
GBR-12935 maleate
|
|
|
|
GBR-12935 is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labe... |
|
T70960 |
Maprotiline-d3 hydrochloride
|
|
|
|
Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selecti... |
|
T83888 |
(S)-5-hydroxy-6-methoxy Duloxetine maleate
|
|
|
|
(S)-5-hydroxy-6-methoxy Duloxetine, an active metabolite of the (S)-duloxetine, functions as a serotonin (5-HT) and norepinephrine reuptake inhibitor. Its formation occurs through the cytochrome P450 (CYP) isoforms CYP1A... |
|
T37800 |
PF-04449613
|
|
|
|
PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50= 22 nM).1It is selective for PDE9A over PDE1C (IC50= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less tha... |
